Publications

The list of full publications can be found in the following link.

Haruwaka K#, Yanlu Ying#, Liang Y, Umpierre AD, Yi MH, Kremen V, Chen T, Xie T, Qi F, ,Zhao S, Zheng J, Liu YU, Dong H, Worrell GA, Wu LJ*. 2024. Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses. Nature Neuroscience, in press .

Zhao S#, Zheng J#, Wang L, Umpierre AD, Parusel S, Xie M, Dheer A, Ayasoufi K, Johnson AJ, Richardson JR, Wu LJ*. 2023. Chemogenetic manipulation of CX3CR1+ cells transiently induces hypolocomotion independent of microglia. Molecular Psychiatry, 28(7):2857-2871 .

Xie M#, Liu YU#*, Zhao S, Zhang L, Bosco DB, Pang Y-P, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ*. 2022. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature Neuroscience, 25(1): 26-38.

Eyo UB#, Haruwaka K#, Mo M, Campos-Salazar AB, Wang L, Speros XS, Sabu S, Xu P, Wu LJ*. 2021. Microglia provide structural resolution to injured dendrites after severe seizures. Cell Reports, 35(5): 109080.

Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ*. 2021. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biology, 19(3): 3001154.

Umpierre AD, Bystrom LL, Ying Y, Liu YU, Worrell G, Wu LJ*. 2020. Microglial calcium signaling is attuned to neuronal activity in awake mice. eLife, 9: e56502.

Chen T, Lennon VA, Liu YU, Bosco DB, Li Y, Yi MH, Zhu J, Wei S, Wu LJ*. 2020. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. Journal of Clinical Investigation, 130(8):4025-4038.

Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ*. 2019. Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Nature Neuroscience, 22(11):1771-1781.

Mo M#, Eyo UB#, Xie M, Peng J, Bosco DB, Umpierre AD, Zhu X, Tian DS, Xu P*, Wu LJ*. 2019. Microglial P2Y12 receptor regulates seizure-induced neurogenesis and immature neuronal projections. Journal of Neuroscience, 39(47):9453-9464.

Zhou LJ#, Peng J#, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Li ZJ, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin WJ, Chen T, Li M, Wang H, Richardson JR, Tan Z*, Liu XG*, Wu LJ*. 2019. Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain. Cell Reports, 27(13):3844-3859.

Eyo UB, Wu LJ*. 2019. Microglia: lifelong patrolling immune cells of the brain. Progress in Neurobiology, 179:10614 (review).

Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis D, Xu P, Wu LJ*. 2018. P2Y12R-dependent translocation mechanisms gate the changing microglial landscape. Cell Reports, 23(4):959-966.

Tian D#, Peng J#, Murugan M, Feng L, Liu J, Eyo UB, Zhou LJ, Mogilevsky R, Wang W*, Wu LJ*. 2017. Chemokine CCL2-CCR2 signaling induces neuronal cell death via STAT3 activation and IL-1β production after status epilepticus. Journal of Neuroscience, 37(33):7878-7892.

Liu Y#, Zhou LJ#, Wang J#, Li D, Ren WJ, Peng J, Wei X, Xu T, Xin WJ, Pang RP, Li YY, Qin ZH, Murugan M, Mattson MP, Wu LJ*, Liu XG*. 2017. TNF-α differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury. Journal of Neuroscience, 37(4): 871-881.

Peng J#, Gu N#, Zhou LJ, Eyo UB, Murugan M, Gan WB, Wu LJ*. 2016. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nature Communications, 7:12029.

Gu N#, Peng J#, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H*, Wu LJ*. 2016. Spinal microgliosis due to resident microglial proliferation is required for pain hypersensitivity after peripheral nerve injury. Cell Reports, 16(3): 605-614.

Eyo UB, Gu N, De S, Dong H, Richardson JR, Wu LJ*. 2015. Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. Journal of Neuroscience, 35(6): 2417-2422.

Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ*. 2014. Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. Journal of Neuroscience, 34(32): 10528-10540.

Wu LJ*. 2014. Voltage-gated proton channel Hv1 in microglia. Neuroscientist, 20 (6): 599-609 (review).

Wu LJ#, Wu G#, Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE*. 2012. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience, 15(4): 565-573.

Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE*. 2012. The channel kinase, TRPM7, is required for early embryonic development. PNAS, 109(5): E225-233.

Wang H#, Xu H#, Wu LJ#, Kim SS#, Chen T, Koga K, Descalzi G, Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M*. 2011. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Science Translational Medicine, 3 (65): 65ra3.

Wu LJ#, Sweet TB#, Clapham DE*. 2010. Current progress in the mammalian TRP ion channel family. Pharmacological Reviews, 62 (3): 381-404 (review).

Slusky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G*. 2010. Enhancement of learning and memory by elevating brain magnesium. Neuron, 65 (2): 165-177.

Wang H#, Wu LJ#, Kim SS#, Lee FJ, Gong B, Toyoda H, Ren M, Xu H, Liu F, Zhao MG, Zhuo M*. 2008. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron, 59 (4): 634-647.

Xu H#, Wu LJ#, Wang H#, Zhang X, Vadakkan KI, Kim SS, Steenland HW, Zhuo M*. 2008. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. Journal of Neuroscience, 28 (29): 7445-7453.

Hines RM#, Wu LJ#, Hines DJ, Steenland H, Mansour S, Dahlhaus R, Singaraja RR, Cao X, Sammler E, Hormuzdi SG, Zhuo M, El-Husseini A*. 2008. Synaptic imbalance, stereotypies and impaired social interactions in mice with altered neuroligin 2 expression. Journal of Neuroscience, 28 (24): 6055-6067.

Wang H, Wu LJ, Zhang F, Zhuo M*. 2008. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by Group I metabotropic glutamate receptors. Journal of Neuroscience, 28 (17): 4385-4397.

Wu LJ, Vadakkan KI, Zhuo M*. 2007. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia, 55 (8): 810-821.

Duan B#, Wu LJ#, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL*. 2007. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. Journal of Neuroscience, 27 (41): 11139-11148.

Zhao MG#, Ko S#, Wu LJ#, Toyoda H#, Xu H, Quan J, Jia Y, Li JG, Ren M, Xu Z, Zhuo M*. 2006. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of the mice with chronic pain. Journal of Neuroscience, 26 (35): 8923-8930.

Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko S, Jia Y, Shum F, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M*. 2005. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. Journal of Neuroscience, 25 (48): 11107-11116.

Zhao MG#, Toyoda H#, Lee YS#, Wu LJ#, Ko S#, Zhang XH#, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M. 2005. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 47 (6): 859-872.

Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL*. 2004. Characterizations of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. Journal of Biological Chemistry, 279 (42): 43716-43724.